Locking pliers and regular pliers differ primarily in their design and functionality. 
Locking pliers, often known as Vise-Grips, have a unique locking mechanism that allows them to clamp onto objects with a strong grip. This mechanism includes an adjustable screw at the handle's end, which sets the jaw's width, and a lever that locks the jaws in place. Once locked, they maintain their grip without continuous pressure from the user, making them ideal for holding objects securely, even when not actively squeezed. This feature is particularly useful for tasks requiring prolonged grip or when both hands are needed for other tasks.
Regular pliers, on the other hand, do not have a locking mechanism. They rely on the user's hand strength to maintain grip, which can be tiring over extended periods. Regular pliers come in various types, such as needle-nose, slip-joint, and diagonal pliers, each designed for specific tasks like cutting, bending, or gripping. They are generally more versatile for quick, simple tasks that require frequent adjustments or repositioning.
In summary, the key difference lies in the locking capability of locking pliers, which provides a hands-free, secure grip, compared to the manual, continuous grip required by regular pliers. This makes locking pliers more suitable for tasks requiring sustained pressure or when working with stubborn materials, while regular pliers are better for tasks needing frequent adjustments and precision.