Lab bottle caps are generally designed to be compatible with both plastic and glass bottles, but compatibility can vary based on specific factors such as the type of cap, the design of the bottle neck, and the intended use. 
1. **Material and Design**: Lab bottle caps are typically made from materials like polypropylene, polyethylene, or phenolic resins, which provide chemical resistance and durability. These materials are suitable for both plastic and glass bottles. However, the design of the cap, including the threading and sealing mechanism, must match the bottle's neck design to ensure a proper fit.
2. **Threading**: The threading on the cap and the bottle neck must be compatible. Standardized threading sizes, such as GL (Glass Labware) or GPI (Glass Packaging Institute) threads, are often used to ensure compatibility across different materials. A cap with a GL45 thread, for example, can fit both plastic and glass bottles with the same thread specification.
3. **Sealing**: The sealing mechanism, such as a liner or gasket, is crucial for ensuring a leak-proof seal. Caps may have different liners (e.g., PTFE, silicone) that are suitable for various chemical applications and can be used with both plastic and glass bottles.
4. **Application**: The intended application can influence compatibility. For instance, high-temperature applications may require specific cap materials that can withstand heat, which may be more relevant for glass bottles.
5. **Manufacturer Specifications**: It's essential to consult manufacturer specifications to ensure compatibility. Some caps are specifically designed for certain bottle types or brands, and using them interchangeably without verification can lead to leaks or contamination.
In summary, while many lab bottle caps are designed to be versatile, ensuring compatibility requires attention to threading, sealing, and manufacturer guidelines.