Negative air machines and regular air cleaners both improve indoor air quality but differ in function and application. 
Negative air machines are primarily used in industrial or construction settings to control air quality by creating a negative pressure environment. They draw air from a contaminated area, filter it through HEPA filters, and exhaust it outside, preventing the spread of contaminants to other areas. These machines are essential in environments requiring containment, such as asbestos removal, mold remediation, or hospital isolation rooms.
Regular air cleaners, or air purifiers, are designed for residential or commercial use to improve air quality by removing pollutants like dust, pollen, smoke, and odors. They typically use a combination of filters, such as HEPA, activated carbon, and sometimes UV light, to clean the air within a room. Unlike negative air machines, they do not create negative pressure or exhaust air outside; instead, they recirculate the filtered air back into the same space.
In summary, negative air machines are specialized for containment and exhaust purposes in high-risk environments, while regular air cleaners are used for general air purification in everyday settings.