Yes, air-powered caulk guns can be used for both indoor and outdoor applications. These tools are versatile and efficient, making them suitable for a variety of caulking tasks in different environments. 
For indoor applications, air-powered caulk guns are ideal for sealing gaps and joints in areas such as bathrooms, kitchens, and around windows and doors. They provide a consistent and smooth application of sealant, which is crucial for achieving a professional finish in interior spaces. The precision and control offered by air-powered caulk guns help in minimizing mess and ensuring that the sealant is applied evenly, which is particularly important in indoor settings where aesthetics are a concern.
For outdoor applications, air-powered caulk guns are equally effective. They can be used for sealing exterior joints, such as those found in siding, roofing, and around outdoor fixtures. The power and efficiency of these tools allow for quick application, which is beneficial when working in outdoor conditions where time and weather can be factors. Additionally, air-powered caulk guns can handle a variety of sealant types, including those designed for outdoor use, which are often more viscous and require more force to apply.
Overall, the adaptability of air-powered caulk guns makes them suitable for both indoor and outdoor projects, providing reliable performance and high-quality results in various environments.