Keyed luggage padlocks are only moderately secure for travel. They can deter casual tampering and keep honest people honest, but they are not strong enough to protect valuables against a determined thief.
Their main weaknesses are that many are small, made with light metal, and use simple key mechanisms that can be picked, shimmed, or cut. Luggage itself is also easy to damage; a thief may ignore the lock and just slice the bag, break the zipper, or access an external pocket. So the lock often protects the zipper pull, not the contents.
For normal airport or hotel travel, a keyed padlock is useful as a basic deterrent, especially for short stops and low-risk situations. It may also help prevent accidental opening or casual snooping. But if you are carrying expensive electronics, documents, or anything irreplaceable, do not rely on it as your main security measure.
Better options are hard-shell luggage with integrated TSA-approved locks, cable locks for securing bags together, and keeping valuables in your carry-on. For checked bags, think of the lock as a signal of “don’t casually open this,” not as real theft protection.
So, yes, keyed luggage padlocks are secure enough for light deterrence and convenience, but not secure enough to fully protect your belongings during travel.