Hydraulic cylinder seals should be replaced based on several factors, including the operating conditions, the type of hydraulic system, and the specific application. Generally, seals should be inspected regularly and replaced when signs of wear or damage are evident. 
1. **Operating Hours**: For systems operating under normal conditions, seals might need replacement every 2,000 to 5,000 operating hours. However, this can vary significantly based on the intensity of use.
2. **Preventive Maintenance Schedule**: Many industries follow a preventive maintenance schedule, replacing seals every 1 to 2 years to avoid unexpected failures.
3. **Signs of Wear**: Seals should be replaced immediately if there are visible signs of wear, such as leaks, cracks, or deformation. Regular inspections can help identify these issues early.
4. **Environmental Conditions**: Harsh environments, such as those with extreme temperatures, abrasive materials, or chemical exposure, may necessitate more frequent seal replacement.
5. **Type of Seal Material**: The material of the seal also affects its lifespan. For example, seals made from high-performance materials like polyurethane or Viton may last longer than those made from standard rubber.
6. **System Pressure and Speed**: High-pressure systems or those with rapid cycling may cause seals to wear out faster, requiring more frequent replacement.
7. **Manufacturer Recommendations**: Always consider the manufacturer's guidelines for seal replacement, as they are tailored to the specific design and materials of the hydraulic system.
In summary, while there is no one-size-fits-all answer, regular inspection and adherence to a maintenance schedule based on the above factors can help determine the optimal replacement frequency for hydraulic cylinder seals.