Spray foam sealant cans and cylinders differ primarily in size, application method, and intended use. 
Spray foam sealant cans are typically smaller, handheld containers designed for consumer use. They are convenient for small-scale projects, such as sealing gaps around windows, doors, and other minor cracks. These cans usually come with a straw applicator, making them easy to use for DIY enthusiasts. The foam expands upon application, providing insulation and air sealing. However, the output is limited, and the foam may not be as dense or durable as that from larger systems.
In contrast, spray foam cylinders are larger, often used by professionals for more extensive projects. They require a separate dispensing gun and hose, allowing for greater control and precision during application. Cylinders are ideal for insulating larger areas, such as walls, attics, and crawl spaces. They offer a higher yield and can cover more surface area efficiently. The foam from cylinders tends to be denser and more robust, providing better insulation and structural support.
Additionally, the formulation of the foam may vary between cans and cylinders. Cylinders often contain two-component foam, which cures faster and provides a more consistent finish. Cans typically contain single-component foam, which may take longer to cure and might not offer the same level of performance.
In summary, spray foam sealant cans are suitable for small, quick fixes and are user-friendly for non-professionals. Cylinders, on the other hand, are designed for larger, professional-grade applications, offering superior performance and efficiency.