Polyurethane and silicone sealants differ in composition, application, and performance characteristics. 
Polyurethane sealants are organic compounds known for their strong adhesion to a variety of surfaces, including wood, metal, and concrete. They are highly durable, offering excellent resistance to abrasion and mechanical wear. Polyurethane is flexible, allowing it to accommodate joint movement, and is often used in construction for sealing expansion joints, windows, and doors. It cures by reacting with moisture in the air, forming a tough, elastic material. However, polyurethane is susceptible to UV degradation, which can lead to discoloration and reduced performance over time.
Silicone sealants, on the other hand, are inorganic compounds that provide superior resistance to UV rays, weathering, and temperature extremes. They maintain their flexibility and adhesion over a wide temperature range, making them ideal for outdoor applications and areas exposed to sunlight. Silicone is often used in glazing, sealing glass, and in applications requiring a waterproof seal. It cures by releasing acetic acid or alcohol, depending on the type, and forms a flexible, rubber-like material. Silicone sealants are generally more expensive than polyurethane and can be less effective on porous surfaces.
In summary, polyurethane sealants are preferred for their strong adhesion and durability in mechanical applications, while silicone sealants are chosen for their excellent weather resistance and flexibility in temperature-varying environments.